New BIO-Complexity Paper: We Could Have Come from Two

first_img Recommended Email Print Google+ Linkedin Twitter Share “A Summary of the Evidence for Intelligent Design”: The Study Guide Requesting a (Partial) Retraction from Darrel Falk and BioLogos Congratulations to Science Magazine for an Honest Portrayal of Darwin’s Descent of Man Human Origins New BIO-Complexity Paper: We Could Have Come from TwoAnn GaugerOctober 21, 2019, 5:58 PM Ann GaugerSenior Fellow, Center for Science and CultureDr. Ann Gauger is Director of Science Communication and a Senior Fellow at the Discovery Institute Center for Science and Culture, and Senior Research Scientist at the Biologic Institute in Seattle, Washington. She received her Bachelor’s degree from MIT and her Ph.D. from the University of Washington Department of Zoology. She held a postdoctoral fellowship at Harvard University, where her work was on the molecular motor kinesin.Follow AnnProfile Share Email Print Google+ Linkedin Twitter Sharecenter_img Editor’s note: We are delighted to announce a new paper by Swedish mathematician Ola Hössjer and Discovery Institute Senior Fellow Ann Gauger in the journal BIO-Complexity. The new research describes scientific work demonstrating that it is possible for the human species to have originated with a pair rather than thousands of individuals. What follows is the first of two posts by Ann describing the work in detail.If you asked pretty much any population geneticist about human origins they would say, “All the evidence says the effective population size has never been below several thousand.” That’s certainly what Dennis Venema thought, and said most emphatically in the book Adam and the Genome:The sun is at the center of our solar system, humans evolved, and we evolved as a population.Put most simply, DNA evidence indicates that humans descend from a large population because we, as a species, are so genetically diverse in the present day that a large ancestral population is needed to transmit that diversity to us. To date, every genetic analysis estimating ancestral population sizes has agreed that we descend from a population of thousands, not a single ancestral couple. (p. 55)He was also quite dismissive of those of us who were working on the problem from a different perspective.[T]here does not appear to be anyone in the antievolutionary camp at present with the necessary training to properly understand the evidence, much less offer a compelling case against it. (Adam and the Genome, p. 65)I suppose Venema can be excused for that statement though he should have been less dismissive. Venema might be excused for saying I wasn’t qualified. But I knew how to find someone who was.  Ola Hössjer of Stockholm University Mathematics Department knows population genetics as well or better than Dennis, and applied mathematics better than that.Teaming UpWhen I first met Ola at a meeting in Copenhagen, we discussed the outlines of what would become the model whose results we report today. The key to addressing the question of our possible origin from two was to model the question directly: start with a population of two and go forward, while keeping track of genetic diversity, to see if we could duplicate the diversity we see in the human population today. The difficulty was that this kind of forward modeling is extremely memory intensive and all but the largest computers cannot go very many generations into the future. Besides that difficulty, I gave him a long list of variables the model should incorporate, an impossible list, I thought.Time passed, and then I had occasion to check in with Ola again. He had a model we now call Haplo that contained within it a simple but brilliant idea. He would start first from current data and use a method called standard coalescence to trace the lineages backward in time, like growing a forest from stems to branches to trunks. Then once he had that forest of trunks, he pruned the picture of all non-productive branches, those that did not have any progeny in the future, the “dead ends,” and used it as a framework for a new forward-looking model. The pruning saved considerable memory and reduced the computational load. This meant we could go deeper in time or handle larger populations. See the figure below.Each row represents a generation, with the present at the bottom, and each ball is a chromosome. The colored dots are different mutations or Single Nucleotide Polymorphisms (SNPs) the chromosome carries. The links from generation to generation show the ancestral lineage of each chromosome going back in time.In figure A, I have shown only one lineage, and so in tracing it backward, there is no pruning necessary, but when a whole collection of coalescence trees are combined (an ancestral recombination graph), some pruning will be necessary, since some chromosomes will be ancestral in some lineages and not others.First the tree (or forest) in reverse is obtained, much larger and complex than this here, and pruned to reveal nothing but the lineages that led to the present. So this provided the framework, the matrix upon which the forward model will run. The computer doesn’t have to keep track of all possible choices at all possible positions. Look at the pruned tree and notice all the spaces the computer doesn’t have to store in memory. It adds greatly to what the program can accomplish.There is one more step in the model description to consider. We proposed to test whether we could have come from two first parents. The model is based on tracking chromosomes—we each have a double set, one from mom and one from dad. In genetic terms a chromosome set is N, and we are diploid, or 2N, creatures. To model two first parents in terms of chromosomes means there are four sets of chromosomes to start out. We don’t start at 1, or 2, we start at 4 on the coalescence tree. See Figure B below.There are two ways to arrive at a situation with two individuals as founders of the human race. One is a sudden extreme bottleneck, from a pre-existing population of thousands down to just two.  This would result in a restriction to just four chromosomes with heterogeneous SNPs on all four chromosomes, but those four chromosomes could still carry 75% of the previous population’s heterozygosity, provided population growth was good, especially in the beginning. This scenario was actually a favored model of speciation for many years. The idea was that sudden isolation would bring a new combination of genes together and lead to new behaviors or morphologies. If the isolation continued the new traits would potentially become the norm and speciation would be complete.  One can imagine this scenario in a world still populated by other hominids, but the pair was isolated in a valley or gorge; one can imagine a scenario more extreme where all hominids except those two were wiped out.The second way to arrive at a single pair as founders would be by a unique origin, de novo, by means unknown. This situation could either have identical chromosomes, mixed chromosomes, or unique chromosomes.Now we have to choose the conditions for running the model: the population growth rate, the mutation rate, the time the simulation runs, and any initial conditions.Our goal was to use as parsimonious a model as possible, to test under a straightforward standard set of assumptions whether it was possible to duplicate current genetic diversity starting from just two individuals.So we chose population growth curves with an initial doubling time of roughly every 10 generations, until a population of 16,000 was reached, where it held steady. This is a reasonable growth rate, assuming mortality is not high. The mutation rate chosen was smack in the middle of reported rates.There is one other factor affecting the model’s results, and it’s very important. It has to do with the initial state of the chromosomes. There are multiple ways the four chromosomes could be modeled: all four identical, with no variation at the start, ab initio, 4 distinct chromosomes with each having unique SNPs, or 4 chromosomes with some SNPs shared and some not. Or they could be mixed in blocks. To get an idea of the possibilities, see the figure below. The distribution of initial diversity has a direct bearing on outcomes.We chose to use the top left scenario with every chromosome unique and no shared SNPs, but other models can be tested in the future. But the other issue is how much!  We will return to that question in a bit.The Fun BeginsWe took the data from the 1000 genomes project and generated a standard Allele Frequency Spectrum for the data. This graph is a standard statistical method for displaying genetic diversity in a population. It is going to take some explaining.Let’s start with what an allele is. An allele in this context is a changed nucleotide at a particular position, so for example, A instead of C in a sequence: AACCGGGATT becomes AAACGGGATTT. The 1000 Genomes Project has kept a record of all the allelic differences in 5008 genomes, or tens of millions of alleles.Each allele in this graph is biallelic, which means there are only two variants, as above, not three or four. That means that if there are 0.2 A (20%) there will be 0.8 C (80%), since the frequency adds up to 1.0 for each position. After going through all the alleles, the number of alleles at each frequency (%) are graphed. Below are the results for the 1000 Genomes Project.The reason for the upswing to the left on all the curves is that mutations are continually happening, and since they happen one at a time, they are by definition very very rare, with a frequency <<<.01. Most of the time new mutations disappear again without a trace but sometimes they increase in frequency and move to the right in the curve, which is why the curve has the slope it does. The difference between Africans and Asians and Europeans is thought to be because Asians and Europeans went through a bottle when they migrated out of Africa, which reduced their genetic variability (they preferentially lost the rare alleles and have had to rebuild them over time).One last population statistic to look at: it is called the Linkage Disequilibrium Graph or LD Graph. In brief, it displays a picture of how tightly linked genes are along the chromosome, which has to do with how often chromosomes recombine during meiosis. (Hang on, I’ll explain.) When eggs and sperm are being made, at a certain stage the chromosome pairs come together and line up tightly, zipping together. Then something remarkable called crossing over, or recombination, happens.  Somewhere along the arm of the chromosome the chromosomes break and the outer pieces form connections with the opposite inner chromosomes. The result is a shuffling of the DNA into new combinations of alleles.[CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)]But other factors can affect linkage as well. Are the interactions between genes that make them necessary in certain combinations or lethal in others? That can serve to keep certain groups of genes tightly coupled. Are there structural reasons why recombination is favored or disfavored in a particular spot? That can also change things.In any case, there is a particular curve associated with LD. Several different statistics have been developed to describe the distribution of LD along chromosomes, from the centromere, which can be thought of as the center or beginning, to the telomere, the outer edge of the chromosome. In the chromosomes pictured above, the centromeres are constrictions a little more than halfway up. The chromosomes have two arms. Some have only one.Without further ado, here are the LD graphs for the 1000 Genomes Project.Start high at the centromere and go low the further out you go. This is called an inverse sigmoidal curve. Chromosome 1 is the largest chromosome and chromosome 22 is the smallest.Now you have the description of the model and the description to the data from the 1000 Genome Project we are trying to match. That is the goal, to find conditions that duplicate the 1000 Genomes curves in a realistic scenario. Oh, and to do it in a parsimonious, minimal way, with as few unusual conditions as possible.Reminder: The population growth curve is doubling every 10 generations until reaching 16,000, standard mutation rate, initial population 2.The only other choice is the amount of initial variation on the chromosome. With a bottleneck scenario there would automatically be variation carried over from the population before, in roughly the same amount as the flat part of the AFS curve, where the vast majority of the population’s variation is. So with the single couple origin, when we chose to put in diversity, we chose to put in that same amount of diversity as for the bottlenecked couple. Other values could of course be chosen; we also ran the model with no initial diversity.So now we come to the moment of the great reveal. A Physician Describes How Behe Changed His MindLife’s Origin — A “Mystery” Made AccessibleCodes Are Not Products of PhysicsIxnay on the Ambriancay PlosionexhayDesign Triangulation: My Thanksgiving Gift to All Some things to notice:Both scenarios have the same conditions: the population starts with 2 doubles every 10 generations until reaching 16,000; 48 mutations per haploid generation, 20 years/generation.Scenario 1: no primordial diversity      Time to match current diversity            2 million yearsScenario 2: with primordial diversity   Time to match current diversity       500 thousand yearsThe Take HomeIt is definitely possible for us to have come from a starting point of two. Whether by a bottleneck or by a unique event the numbers say it is possible. 2 million years corresponds to the time of the first hominid to be called Homo, Homo erectus. His exact time and place of origin are unknown but are thought to be in Africa. The 500,000-year mark is near the time of the Neanderthals and Denisovans.But these numbers are not fixed in stone. They are subject to change: a change in population structure, mortality, mutation rate, birth rate, migration, selection, all can influence the results. The amount of initial diversity, or its distribution, can as well. Changing the population size or time by half can be reversed by multiplying the mutation rate by two. In other words, we have a relationship than can be tweaked and studied, and its parameters can be worked out, but as one of its creators said, the model is “underdetermined.” That’s putting it mildly.Once again, the precise age of the first couple is not the main point of this study. That there could be a first couple at all is the point.Image credit: Johannes Plenio via Unsplash. Jane Goodall Meets the God Hypothesis Origin of Life: Brian Miller Distills a Debate Between Dave Farina and James Tour Tags1000 Genomes ProjectAnn GaugerBIO-ComplexityDarwingeneticshuman evolutionhuman originsOla Hössjerpopulation genetics,Trendinglast_img read more

Air Force reservist fatally stabbed in road rage incident; relatives want ‘monster’ caught

first_imgiStock/Thinkstock(NEW YORK) — A U.S. Air Force veteran was stabbed to death after a road rage incident — and now cops are looking for the driver who allegedly killed him, Missouri police said.Cody Harter, 24, was driving his maroon Chevy C71 extended cab truck about 7:30 p.m. Saturday when he allegedly pulled over to a median between Interstate 470 and MO-291.That’s where he exchanged words with another driver, police said.“It appears our victim was in traffic and involved in some type of altercation with another person in traffic,” said Chris Depue, a spokesman for Lee’s Summit Police Department.Depue said many witnesses may have seen “some type of altercation” unfold between Harter and another man at the merger between the two thruways.“Two cars are on the shoulder and [witnesses] saw two men outside those vehicles arguing in what appeared to be a disturbance or a fight,” he said.The dispute escalated and the unidentified motorist allegedly stabbed Harter before fleeing in his vehicle north on I-471, police said.That driver is still on the lam, police said. Authorities did not say if witnesses provided descriptions of him or the vehicle he was driving.Before the incident, Harter’s family said he called them to let them know he was on his way home.“He came down yesterday to pick up a mower,” Harter’s father, Mike, said Sunday. “He called his mom on the way home and said, ‘I love you. I’ll be home in just a bit.’”The family made a heart wrenching plea to urge any witness who may have seen what happened to come forward to help track down the alleged killer.“If you saw anything, even if you think it as nothing — please call,” the senior airman’s mother, Kerrie, said through tears. “Let’s find who did this senseless act so you’re not sitting here when it’s your child. Please call and send us a message… Please.”Kerrie Harter was flanked by her husband, their daughter Shelby, his fellow Air Force reservist, Armando, and Harter’s girlfriend Kylee.In a state of devastation and disbelief, Kerrie Harter said she was still hoping this was not real.“I keep waiting for someone to tell me it’s not true,” she said. “That I’m going to wake up from this. But I’m not.”She said that while son managed to survive overseas fighting and protecting the country in deployment tours to Iraq and Qatar — and helping in hurricane relief efforts in Houston and Puerto Rico — he somehow died on a domestic road over what cops care calling a road rage incident.“He had been to war and back, and to die because someone was angry,” she said, stopping mid-sentence. “My son drove 65 MPH because he was so frugal with his gas mileage.“I can only imagine someone was upset because he wasn’t going fast enough,” she continued. “But that’s not a reason to take his life and leave him there.”His sister called out the killer for ditching her brother after whatever dispute the two may have had.“I think you’re a monster,” Shelby Berkemeier said. “You not only took my brother’s life but you took everything away from us.”Sitting by her and holding hands was Harter’s girlfriend, Shelby.She could barely say any words — only that she had planned to marry Harter and felt as though she and the family “were in a dark place right now.”“He was the love of my life,” she said.Harter’s mother said her son died away in the arms of other good Samaritan drivers who spotted him stumbling into traffic.“I want to thank all the people that stopped and held his hand and prayed with him,” she said. “Whoever did this may have thought he died alone. He did not die alone.”Harter was in his final semester at Missouri Western State University in St. Joseph to earn a degree in engineering technology. When he wasn’t racing dirt bikes he was mowing lawns for a small business he started, his family said.“He loved his lawn care business because he could mow when he wanted to and get to the dirt track on weekends,” Kerrie Harter said proudly.And now she and the family are being forced to say goodbye.“We’re going to go home and go to the funeral home to make arrangements to bury my son,” she said, breaking down in tears.Then she recovered and said: “I don’t want another mother to sit here.”Copyright © 2018, ABC Radio. All rights reserved.last_img read more

Coronavirus live updates: US surgeon general urges Americans to get flu shot

first_imgMyriam Borzee/iStockBy MORGAN WINSOR, ABC News(NEW YORK) — A pandemic of the novel coronavirus has now infected more than 67.1 million people and killed over 1.5 million worldwide, according to real-time data compiled by the Center for Systems Science and Engineering at Johns Hopkins University.Here’s how the news is developing Monday. All times Eastern:Dec 07, 9:14 amUK prepares for Tuesday’s rollout of COVID-19 vaccinationsDoses of the COVID-19 vaccine developed by U.S. pharmaceutical giant Pfizer and its German partner BioNTech have been delivered across the United Kingdom, ahead of the launch of the country’s immunization program.The potentially-life saving vaccine will be administered nationwide starting Tuesday morning, and some 800,000 doses were expected to be in place for the first day of what will be the largest-scale immunization program in U.K. history.Vaccinations will be rolled out in phases, with elderly care home residents and their carers first on the priority list, followed by anyone else aged 80 and over, as well as frontline health and social care workers.Last week, the U.K. became the first country in the world to authorize the Pfizer/BioNTech vaccine for emergency use. The vaccine was shown in late-stage clinical trials to be more than 95% effective in preventing COVID-19.Dec 07, 8:26 amBiden transition team says Trump administration still hasn’t shared vaccine distribution plansU.S. President-elect Joe Biden’s transition team said the Trump administration still has not shared its distribution plans for COVID-19 vaccines.“We have yet to see any kind of detailed plan,” Dr. Celine Gounder, an infectious disease specialist who is a member of Biden’s transition COVID-19 advisory board, said in an interview Monday on CBS This Morning.“We really need to understand what their plan for distribution is,” she added. “We’ve already been trying to get a handle on how many doses will be available to us from each of the companies and by when, but we do need some internal information on that from the federal government. We also need to understand where they are with their plans.”Dec 07, 8:07 am‘My colleagues are dog-tired,’ US surgeon general says in plea to AmericansU.S. Surgeon General Jerome Adams urged people to take the coronavirus pandemic seriously and follow public health guidelines as infections and hospitalizations soar across the country.“I want the American people to know this virus is incredibly unforgiving, cases are going up, hospitalizations are going up, my colleagues are dog-tired and we need you to hang on just a little bit longer because we’ve got vaccines coming but we want as many people to be alive to get them as possible and a lot of that is going to depend on your behavior,” Adams told ABC News chief anchor George Stephanopoulos in an interview Monday on Good Morning America.Although “more people than ever are wearing masks,” Adams said he’s “very” concerned by the number of people who still “don’t understand how much spread is occurring by people who don’t have symptoms.”About 20 million “full doses” of COVID-19 vaccines will be available by the end of the year, according to Adams, who urged every American to be immunized against the virus as soon as a vaccine is authorized and made available.“It’s a way that we can ultimately end this pandemic, but it doesn’t matter if people won’t get the vaccination,” the surgeon general said. “We know that vaccine levels are only about 50% for adults for flu and they go down to about 40% for African-Americans.”Adams said he is working with historically black colleges and universities as well as faith communities to bolster vaccine confidence among all populations. The White House is also hosting a vaccine summit Tuesday, he said.“One thing you can all do right now, it’s national flu immunization week, get your flu shot because half a million people were hospitalized last year with the flu,” Adams said. “We simply can’t afford for that to happen this year with hospitals being overwhelmed.”The surgeon general said the current surge in infections across the country “is different than earlier surges,” because it’s not about a lack of masks or personal protective equipment, nor is it due to a lack of testing.“It’s really about health care capacity, and certain places are just being overwhelmed,” he said. “So we know that we can actually help them with their health care capacity by immunizing their health care staff. We’re going to leave it up to the states, but we’re going to give them guidance.”Adams noted it’s also important to vaccinate those who are most likely to die from COVID-19.“We know that 40 to 50% of the deaths are occurring in people who are in longterm care facilities who are older,” he said.Dec 07, 7:29 amHong Kong installs vending machines for COVID-19 test kitsHong Kong has installed vending machines for COVID-19 test kits in 10 subway stations across the semi-autonomous Chinese territory.The regional government said it will be supplying about 10,000 self-administered test kits to the mass transit authority for distribution to the vending machines across all 10 stations daily, according to a press release.Hongkongers can purchase the kits using their Octopus transit card.A recent surge in COVID-19 cases has prompted Hong Kong authorities to tighten restrictions, including banning most social gatherings to just two people. Another 95 new cases were confirmed on Sunday, bringing Hong Kong’s total to 6,898 cases with at least 112 deaths.Dec 07, 6:57 amBiden announces key members of health teamU.S. President-elect Joe Biden on Monday announced key nominations and appointments of his health team, a slate of experts and public officials who will lead his administration’s response to the coronavirus pandemic.“This trusted and accomplished team of leaders will bring the highest level of integrity, scientific rigor and crisis-management experience to one of the toughest challenges America has ever faced — getting the pandemic under control so that the American people can get back to work, back to their lives and back to their loved ones,” Biden said in a statement. “This team of world-class medical experts and public servants will be ready on day one to mobilize every resource of the federal government to expand testing and masking, oversee the safe, equitable and free distribution of treatments and vaccines, reopen schools and businesses safely, lower prescription drug and other health costs and expand affordable health care to all Americans, and rally the country and restore the belief that there is nothing beyond America’s capacity if we do it together.”California Attorney General Xavier Beccera is nominated to serve as the Secretary of Health and Human Services.Dr. Vivek Muthy, a physician and research scientist, is nominated to be the Surgeon General, a role he served during the Obama administration.Dr. Rochelle Walensky, an expert on virus testing, prevention and treatment, is nominated to serve as director of the Centers for Disease Control and Prevention.Dr. Marcella Nunez-Smith, an expert on health care disparities, will serve as the COVID-19 Equity Task Force Chair.As Biden said last week, Dr. Anthony Fauci will stay on in his current role as director of the National Institute of Allergy and Infectious Diseases. Fauci will also serve as Biden’s chief medical adviser on COVID-19.Jeff Zients, co-chair of Biden’s transition team who led the Obama administration’s National Economic Council, will serve as coordinator of the COVID-19 Response as well as counselor to the president.Natalie Quillian, a national security expert, will serve as deputy coordinator of the COVID-19 response.Dec 07, 6:14 amGermany to begin COVID-19 vaccinations in early JanuaryCOVID-19 vaccinations are expected to begin in Germany “in the very first days” of 2021, according to German Chancellor Angela Merkel’s chief of staff.In an online interview Sunday with German newspaper Bild, Helge Braun said he and Merkel will get vaccinated “when it’s our turn.” The trained doctor also noted that he’s prepared to help vaccinate people himself.“That won’t work at every hour of the day or night as chief of staff, but at the weekend I’m prepared to join in,” Braun told the Bild.The European Union’s drug regulator is expected to make a decision by Dec. 29 on approving the first COVID-19 vaccine for use. In the meantime, Germany is preparing special vaccination centers.Dec 07, 4:41 amUS reports over 175,000 new casesThere were 175,663 new cases of COVID-19 confirmed in the United States on Sunday, according to a real-time count kept by Johns Hopkins University.It’s the 34th straight day that the U.S. has reported over 100,000 newly diagnosed infections. Sunday’s tally is less than the country’s all-time high of 227,885 new cases confirmed on Dec. 4, according to Johns Hopkins dataAn additional 1,114 deaths from the disease were also registered nationwide on Sunday, down from a peak of 2,879 fatalities on Dec. 3, according to Johns Hopkins data.COVID-19 data may be skewed due to possible lags in reporting over Thanksgiving followed by a potentially very large backlog from the holiday.A total of 14,760,627 people in the U.S. have been diagnosed with COVID-19 since the pandemic began, and at least 282,312 of them have died, according to Johns Hopkins data. The cases include people from all 50 U.S. states, Washington, D.C., and other U.S. territories as well as repatriated citizens.Much of the country was under lockdown by the end of March as the first wave of pandemic hit. By May 20, all U.S. states had begun lifting stay-at-home orders and other restrictions put in place to curb the spread of the novel coronavirus. The day-to-day increase in the country’s cases then hovered around 20,000 for a couple of weeks before shooting back up over the summer.The numbers lingered around 40,000 to 50,000 from mid-August through early October before surging again to record levels, crossing 100,000 for the first time on Nov. 4 and reaching 200,000 for the first time on Nov. 27.Copyright © 2020, ABC Audio. All rights reserved.last_img read more

Russian trek for Germany’s V. Alexander

first_imgThe consignment was made up of heavy compressor stations, the largest of which weighed 39 tons (35.4 tonnes).The recipient was a Russian military base and therefore V. Alexander had to provide highly stringent shipment documentation including: block Customs clearance; extremely precise pre-notices about the arrival of trucks; as well as vehicle driver names and identification documents.Adding to the difficulty of the shipment, parts of the 3,500 km route were subject to extreme winter weather conditions.www.valexander-bremen.dewww.cargoequipmentexperts.comlast_img read more

Tobacco use remains a concern for health officials

first_img Share 184 Views   one comment The Ministry of Health is taking action to reduce the health risks associated with tobacco use. Permanent secretary in the Ministry of Health Helen Royer, in an address to the nation on 4 June 2015 to commemorate World No Tobacco Day which was observed on 31 May, expressed concern about the high rate of exposure of non-smokers to the dangers of tobacco smoke.”In Dominica although smoking is prevalent among adults (the estimation is one in every ten adults), the 2009 survey shows that smoking among students 13-15 years stands at one in four,” Mrs Royer stated.“The survey also reveals that six of every ten non-smoking students and one of every five adults are exposed to tobacco smoke in public spaces. Clearly the youths of Dominica are at risk to diseases both caused by their own actions and from the actions of others,” she continued. Mrs Royer said the Ministry of Health and Environment is also in the process of making recommendations to the government to create policies which will contribute to the improvement of the health of the nation.She said the ministry acknowledges that it is the responsibility of all stakeholders to protect the health of both smokers and non-smokers from the poisons in tobacco smoke.Every year, on 31 May, the World Health Organization (WHO) and partners mark World No Tobacco Day, highlighting the health risks associated with tobacco use and advocating for effective policies to reduce tobacco consumption.This year, the focus in Dominica is on the theme” “The Harmful Effects of Tobacco: Beware”.Mrs Royer informed that the ministry will be observing a month of activities which will include public education, media discussion, town hall meeting and poetry competition and encouraged the public to participate. Mrs. Royer said the ministry is also in the process of making recommendations to the government to create policies which will contribute to the improvement of the health of the nation.“The public, as a major stakeholder, also has important roles to play in: Advocacy, Provision of support to raise awareness on tobacco, Provision of support to quit tobacco and more,” she said. Mrs Royer has urged the public to take all the necessary preventive measures to reduce their risks associated to tobacco use.Some conditions which are the results of either direct or indirect tobacco smoke include Cancer of the lungs, mouth and throat, Chronic bronchitis and emphysema, Heart Disease, Miscarriages, Infertility and sexual dysfunction among others.According to the World Health Organization nearly 80% of the more than one billion smokers worldwide live in low- and middle-income countries, where the burden of tobacco-related illness and death is heaviest.Tobacco users who die prematurely deprive their families of income, raise the cost of health care and hinder economic development. Tweet Sharecenter_img Sharing is caring! LocalNews Tobacco use remains a concern for health officials by: Dominica Vibes News – June 4, 2015 Sharelast_img read more

Dominant D carries Manning, Broncos to 24-10 Super Bowl win

first_imgDenver Broncos’ Von Miller (58) strips the ball from Carolina Panthers’ Cam Newton (1) during the second half of the NFL Super Bowl 50 football game Sunday, Feb. 7, 2016, in Santa Clara, Calif. (AP Photo/Charlie Riedel)SANTA CLARA, Calif. (AP) — With his prolific passing and complete control of the game at the line of scrimmage, Peyton Manning helped usher in the NFL’s wide-open era of high-scoring offenses and pass-happy game plans. Manning’s possible farewell game in Super Bowl 50 was a throwback to the 1970s when his father Archie was running away from dominant defenses such as the Steel Curtain and Doomsday.Von Miller forced fumbles that set up both of Denver’s touchdowns, led a defense that harassed MVP Cam Newton and helped carry Manning to his second Super Bowl title with a 24-10 victory over the Carolina Panthers on Sunday.“Whenever you’re doing something for your buddies, it means a little bit more,” Miller said. “As human beings, we’re selfish but when you’re doing something for somebody else, that’s when the magic happens.”  For so many years, Manning’s career was defined by his gaudy regular season numbers that weren’t enough come playoff time. A lack of help from teammates or the inability to thrive against stellar defenses from teams such as New England and Seattle left Manning with just one Super Bowl title in his first 13 playoff trips. So perhaps it was fitting that after carrying teammates for most of his career, he was carried over the finish line in this game by Miller and the coordinator Wade Phillips’ “Orange Rush” defense.“I certainly knew that (with) this defense, this team would have a chance,” Manning said. “Our defense has just been, from the get-go, they’ve been nothing but awesome. Being hurt and struggling early in the season wasn’t a lot of fun so I was grateful to get back healthy and to try and play my part these last couple of weeks.”But now after throwing for more yards, more touchdowns and winning more starts than any other quarterback in NFL history, Manning could be ready to hang it up. Manning wouldn’t say after the game whether this was his final one.“I got some good advice from Tony Dungy,” Manning said of the first of four coaches with whom he’s been to the Super Bowl. “He said, ‘Don’t make an emotional decision.’ This has been an emotional week, an emotional night. I’m going to take some time to reflect.”Miller set the tone early when he blew past right tackle Mike Remmers and ripped the ball out of Newton’s grasp. Malik Jackson recovered the ball in the end zone for a touchdown to put Denver up 10-0.Then in the fourth quarter with the Broncos protecting a 16-10 lead, Miller struck again. Once again, he got around Remmers and knocked the ball out of Newton’s hands. T.J. Ward recovered at the 4 and C.J. Anderson sealed it with a TD run.“In my opinion, we’re the greatest defense to ever play the game,” linebacker Brandon Marshall said. “Ever. It’s a bold statement but top to bottom, we have the greatest talent — from rushers to safeties to linebackers. Better than anybody’s ever done it.”After knocking off former Super Bowl champions Ben Roethlisberger and Tom Brady to make it here and then holding Newton and the NFL’s highest-scoring offense to its lowest point total of the season, the Broncos stated their case to stand next to Pittsburgh’s Steel Curtain defenses of the 1970s, the dominant 1985 Chicago Bears, the 2000 Baltimore Ravens, the 2002 Tampa Bay Buccaneers and the 2013 Seattle Seahawks on the list of top defenses.Denver recorded 14 sacks, forced seven turnovers and allowed just four touchdowns in the three playoff wins.“This is the rawest defense ever. Ever,” Denver tight end Owen Daniels said. “To do that to the guy that’s changing the game, unbelievable. Our defense, you have to put them up there with the best ever.”The Panthers defense was just about as stingy, but couldn’t come up with the game-changing turnovers that Denver provided. Carolina held Denver to 194 yards — the fewest ever for a Super Bowl winner — and didn’t allow a first down on eight of 14 drives.But it wasn’t enough.“It’s so gut-wrenching and hard to swallow that,” All Pro cornerback Josh Norman said. “There were chances and opportunities there and we just didn’t capitalize on them.”Newton, who threw for 38 touchdowns and ran for 12 in his first 18 games, produced no touchdowns for the first time all season. Denver tied a Super Bowl record with seven sacks and frustrated the player nicknamed Superman.It didn’t help that Newton’s receivers dropped passes and the running game never got going against Denver’s stout front.“They made more plays than us and that’s what it comes down to,” Newton said during a brief three-minute interview. “We had our opportunities and it was nothing special that they did. We dropped balls. We turned the ball over. We gave up sacks. We threw errant passes. That’s it.”___Online:AP NFL website: www.pro32.ap.org and www.twitter.com/AP_NFLcenter_img  For so many years, Manning’s career was defined by his gaudy regular season numbers that weren’t enough come playoff time. A lack of help from teammates or the inability to thrive against stellar defenses from teams such as New England and Seattle left Manning with just one Super Bowl title in his first 13 playoff trips. So perhaps it was fitting that after carrying teammates for most of his career, he was carried over the finish line in this game by Miller and the coordinator Wade Phillips’ “Orange Rush” defense.“I certainly knew that (with) this defense, this team would have a chance,” Manning said. “Our defense has just been, from the get-go, they’ve been nothing but awesome. Being hurt and struggling early in the season wasn’t a lot of fun so I was grateful to get back healthy and to try and play my part these last couple of weeks.”But now after throwing for more yards, more touchdowns and winning more starts than any other quarterback in NFL history, Manning could be ready to hang it up. Manning wouldn’t say after the game whether this was his final one.“I got some good advice from Tony Dungy,” Manning said of the first of four coaches with whom he’s been to the Super Bowl. “He said, ‘Don’t make an emotional decision.’ This has been an emotional week, an emotional night. I’m going to take some time to reflect.”Miller set the tone early when he blew past right tackle Mike Remmers and ripped the ball out of Newton’s grasp. Malik Jackson recovered the ball in the end zone for a touchdown to put Denver up 10-0.Then in the fourth quarter with the Broncos protecting a 16-10 lead, Miller struck again. Once again, he got around Remmers and knocked the ball out of Newton’s hands. T.J. Ward recovered at the 4 and C.J. Anderson sealed it with a TD run.“In my opinion, we’re the greatest defense to ever play the game,” linebacker Brandon Marshall said. “Ever. It’s a bold statement but top to bottom, we have the greatest talent — from rushers to safeties to linebackers. Better than anybody’s ever done it.”After knocking off former Super Bowl champions Ben Roethlisberger and Tom Brady to make it here and then holding Newton and the NFL’s highest-scoring offense to its lowest point total of the season, the Broncos stated their case to stand next to Pittsburgh’s Steel Curtain defenses of the 1970s, the dominant 1985 Chicago Bears, the 2000 Baltimore Ravens, the 2002 Tampa Bay Buccaneers and the 2013 Seattle Seahawks on the list of top defenses.Denver recorded 14 sacks, forced seven turnovers and allowed just four touchdowns in the three playoff wins.“This is the rawest defense ever. Ever,” Denver tight end Owen Daniels said. “To do that to the guy that’s changing the game, unbelievable. Our defense, you have to put them up there with the best ever.”The Panthers defense was just about as stingy, but couldn’t come up with the game-changing turnovers that Denver provided. Carolina held Denver to 194 yards — the fewest ever for a Super Bowl winner — and didn’t allow a first down on eight of 14 drives.But it wasn’t enough.“It’s so gut-wrenching and hard to swallow that,” All Pro cornerback Josh Norman said. “There were chances and opportunities there and we just didn’t capitalize on them.”Newton, who threw for 38 touchdowns and ran for 12 in his first 18 games, produced no touchdowns for the first time all season. Denver tied a Super Bowl record with seven sacks and frustrated the player nicknamed Superman.It didn’t help that Newton’s receivers dropped passes and the running game never got going against Denver’s stout front.“They made more plays than us and that’s what it comes down to,” Newton said during a brief three-minute interview. “We had our opportunities and it was nothing special that they did. We dropped balls. We turned the ball over. We gave up sacks. We threw errant passes. That’s it.”___Online:AP NFL website: www.pro32.ap.org and www.twitter.com/AP_NFL,Manning’s possible farewell game in Super Bowl 50 was a throwback to the 1970s when his father Archie was running away from dominant defenses such as the Steel Curtain and Doomsday.Von Miller forced fumbles that set up both of Denver’s touchdowns, led a defense that harassed MVP Cam Newton and helped carry Manning to his second Super Bowl title with a 24-10 victory over the Carolina Panthers on Sunday.“Whenever you’re doing something for your buddies, it means a little bit more,” Miller said. “As human beings, we’re selfish but when you’re doing something for somebody else, that’s when the magic happens.”last_img read more

Racing world in mourning at death of J.T McNamara

first_imgJOHN THOMAS McNAMARA, the former leading Irish amateur rider, has died at the age of 41. McNamara, who was widely considered to be one of the leading amateur riders of his generation, was paralysed after suffering a broken neck after a fall on Galaxy Rock at the 2013 Cheltenham Festival. It was 15 months before McNamara was able to return home from Southport hospital having been paralysed from the neck down, but gained many admirers for his courage in the face of adversity. As a rider, McNamara will be remembered by many for his ice-cool performance aboard the tricky ‘Rith Dubh’ in the 2002 National Hunt Chase at the Cheltenham Festival where his patience and horsemanship came to the fore as he coaxed ‘Rith Dubh’ ahead on the line. He also won the National Hunt Chase in 2012 aboard ‘Tea for three’, the Foxhunters’ Chase in 2007 on ‘Drombeag’ and the 2005 Cross Country Chase on ‘Spot the difference’.print WhatsApp Facebook Twitter Email CHELTENHAM, ENGLAND – MARCH 14: J T McNamara riding Teaforthree win The Diamond Jubilee National Hunt Steeple Chase on ladies day during day two of the Cheltenham Festival at Cheltenham racecourse on March 14, 2012 in Cheltenham, England. (Photo by Alan Crowhurst/Getty Images)last_img read more

Connacht Cup 4th Round Draw

first_imgv 8               Boyle Celtic 4               Ballisodare Utd Home All Cup & Shield Games decided on the day if still a draw after 90 minutes plus one period of extra time (10 minutes E/W) FIFA Rules on Penalty’s to apply. Any Club / Team forfeiting a fixture will be removed from the competition and disciplinary action will follow. v Moore Utd 5                Carbury FC Loughrea v St Bernards T P Brennan Connacht Shield Quarter Final Fixtures Sunday 4th March 2018 2             Hudson Bay FCvSwinford MacDara West Utd v Straide & Foxford 3             Real TubbervWest Coast Utd 7              Merville Utdcenter_img 4             Kilkerrin UtdvManulla B v 1Colemanstown UtdvCorrib Celtic B T P Brennan Connacht Cup 4th Round Fixtures Sunday 11th February 2018 3                Castlebar Celtic v Achill RoversSun 18th Feb v Corrib Rangers Away Away 6                 St Peters print WhatsApp Facebook Twitter Email Home v 2  Renmore/Ballinasloe Town 1Mervue Utdlast_img read more

Defender Cameron Carter-Vickers joins Swansea on season-long loan deal

first_imgTOTTENHAM defender Cameron Carter-Vickers is heading back to the Championship after signing a season-long loan deal with Swansea City.The 20-year-old USA international spent the first half of last campaign at Sheffield United before switching to Ipswich Town for the remainder of the season.4 Cameron Carter-Vickers will spend the season on loan at Swansea CityCredit: Getty – ContributorThis summer he signed a new long-term contract with Spurs until 2021 but, with fierce competition for places in Mauricio Pochettino’s team, the club are happy for the young prospect to gain regular playing opportunities elsewhere.The defender was linked with a number of Championship clubs, with the loan window for English Football League clubs open until August 31.Swansea were on the lookout for defensive reinforcements after selling centre-backs Alfie Mawson, Federico Fernandez, Kyle Bartley and Jordi Amat this summer.And the Swans managed to land their target in Carter-Vickers.4 Carter-Vickers played for Sheffield United and Ipswich Town last seasonCredit: Getty – Contributor4 The USA international joined the Spurs academy as an 11-year-oldCredit: AFP or licensorsHe told the club’s website: “I am super excited. Swansea is a massive club and I can’t wait to get out training with the boys.“When I spoke to the manager [Graham Potter] he told me how they wanted to play.“I have watched them play a few times this season and you can see they play good football. I am looking forward to being part of that.”Carter-Vickers, who has played for his country four times, watched on as Swansea’s unbeaten start to the season came to an end on Saturday with defeat to Bristol City.Cameron Carter-Vickers has joined Swansea City on loan for the remainder of the season, subject to international clearance.Good luck, @cameroncv2. pic.twitter.com/uZNcPSsIuQ— Tottenham Hotspur (@SpursOfficial) August 25, 2018 4 The 20-year-old is not short of Championship experienceCredit: REUTERSMost read in footballRETRACING STEPSJack Charlton’s granddaughter Emma Wilkinson ‘would love’ to visit IrelandROY RAGEFurious Roy Keane launched foul-mouthed rant at Pique over Fabregas friendshipPicturedTOP FORMBrazil icon Ronaldo soaks up sun with partner Celina Locks on yacht in FormenteraPicturedON THE PAOLPaolo Maldini shows off shredded physique at 52 while on holiday with wifeExclusiveLOCK CLOWNPaul Scholes flouts local lockdown rules by throwing huge 7-hour birthday bashLive BlogUNITED LATESTMan Utd transfer news LIVE: All the gossip and updates from Old TraffordPotter said: “It’s an area of the pitch that we need help in and competition because we’ve got Mike [van der Hoorn] and Joe [Rodon].”He [Carter-Vickers] has had experience in the Championship last year and the year before as well.”He’s been at Tottenham, he’s got some really good attributes that we can use and we’re looking forward to working with him and helping him improve. Hopefully he can help us.”Mauricio Pochettino believes that Tottenham can win at Old Trafford for the first time since under Tim Sherwood in 2014last_img read more

Marshfield girls basketball rips Wausau East

first_imgEight Tigers score in road victoryBy Paul LeckerSports ReporterWAUSAU — The Marshfield girls basketball team rolled to its sixth-straight victory with a 54-12 drubbing of Wausau East on Friday night at East High School.Marshfield led 27-7 at halftime and held the Lumberjacks to just five points in the second half to roll to the win. The Tigers are now 13-1 overall and 6-0 in the Wisconsin Valley Conference. East is now 1-12 and 0-6 in the Valley.Marshfield held East to just 9 percent shooting (4 of 43) from the field and forced 24 turnovers.Ema Fehrenbach had 16 points, McKayla Scheuer added 10 points, and Hannah Meverden had 10 points and 11 rebounds to pace the Tigers.Eight of the nine Tigers scored in the game, and reserve guards Dani Bender (seven), Ana Jensen (six), and Corraine Johnson (six) had solid rebounding games for Marshfield.Marshfield has a week off before traveling back to Wausau to play West on Jan. 22 at 7:30 p.m. The game will be broadcast on WDLB-AM 1450 and wdlbwosq.com.(Hub City Times Sports Reporter Paul Lecker is also the publisher of MarshfieldAreaSports.com.)Tigers 54, Lumberjacks 12Marshfield 27 27 – 54Wausau East 7 5 – 12MARSHFIELD (54): McKayla Scheuer 5-9 0-0 10, Dani Bender 1-5 0-2 2, Ana Jensen 1-6 0-3 2, Sara Dasler 1-3 0-0 2, Corraine Johnson 0-1 0-0 0, Meg Bryan 4-9 0-0 8, Maddie Nikolai 2-9 0-0 4, Ema Fehrenbach 5-12 6-7 16, Hannah Meverden 5-9 0-0 10. FG: 24-63. FT: 6-12. 3-pointers: 0-5 (Johnson 0-1, Meverden 0-1, Bryan 0-3). Rebounds: 45 (Meverden 11). Turnovers: 17. Fouls: 9. Fouled out: none. Record: 13-1, 6-0 Wisconsin Valley Conference.WAUSAU EAST (12): McDonald 0-3 0-0 0, Xiong 0-2 0-0 0, Hess 0-2 0-0 0, Urmanski 2-12 0-2 4, Murphy 0-6 2-4 2, Murphy 1-4 1-1 3, Komrei 0-0 0-0 0, Watters 1-12 1-2 3, Twerberg 0-2 0-0 0. FG: 4-43. FT: 4-9. 3-pointers: 0-10 (McDonald 0-1, Murphy 0-2, Urmanski 0-3, Watters 0-4). Rebounds: 20 (Murphy 5). Turnovers: 24. Fouls: 11. Fouled out: none. Record: 1-12, 0-6 Wisconsin Valley Conference.last_img read more